 |
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| How do cells divide? |
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 How are cleavage forces distributed across the cell cortex? |
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| What regulates cortical contraction or relaxation? |
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| What is the role of chromosomes and spindle poles? |
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| What is the role of microtubule motor proteins? |
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| What is the role of protein phosphorylation and degradation? |
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| What is the relationship between microtubules and cell cortex? |
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| How do adherent cells migrate? |
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| How do cells generate traction forces? |
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| How do cells regulate and coordinate traction forces? |
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| How do cells regulate the assembly and disassembly of focal adhesions? |
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| How do cells regulate the expansion and retraction of lamellipodia? |
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| How do cells migrate in a 3D environment? |
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| How do physcial forces affect cell behavior? |
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| How do adhesive substrates guide cell movement? |
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| How do mechanical forces guide cell movement? |
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| How do cells detect external mechanical forces? |
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| How do adhesive substrates affect cortical structure and contraction? |
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| Development of Imaging Technology |
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| Technology for detecting single molecules in living cells. |
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| Technology for detecting molecular interactions in living cells. |
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| Technology for detecting mechanical interactions in living cells. |
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| Technology for processing images of limiting S/N. |
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| Technology for applying mechanical stimuli to living cells. |
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| Technology for high resolution imaging of cells in 3D environment. |
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|
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| Research in this laboratory is supported by NIH and NASA |
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Last modified on Monday, 01-Mar-2004 07:55:58 EST
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