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| Effects of Profilin and Profilin-Actin Complexes on Cell Motility |
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| L.-g. Cao, G.G. Babcock, P.A. Rubenstein and Y.-l. Wang (1992) |
| J. Cell Biol. 117:1023-1029. |
| Profilin is first identified as an actin monomer sequestration protein, but is later found to allow or even promote the assembly of actin monomers to the "barbed" end of actin filaments. To investigate the cellular function of profilin, cultured Normal Rat Kidney cells were microinjected with a large amount of profilin or profilin-actin complexes. |
| Effects of Microinjected Profilin on Lamellipodial Activity |
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Size = 256 x 156 pixels.| The cell to the left was microinjected with a high concentrations of profilin. Its lamellipodia showed a reduced size but nevertheless remained active. |
| Effects of Microinjected Profilin-Actin Complexes on Lamellipodial Activity |
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Size = 256 x 230 pixels.| The cell to the left was microinjected with a high concentration of profilin-actin high affinity complexes. Its lamellipodia showed an increased size and ruffled very actively. |