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| Effects of a High Molecular Mass Tropomyosin on Organelle Transport |
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| R.J. Pelham Jr., J.J.-C. Lin and Y.-l. Wang (1996) |
| J. Cell Sci. 109:981-989. |
| Cultured cells were microinjected with a large amount of tropomyosin, to probe their cellular functions based on the effects of "over-expression". |
| Regrograde Movement of Organelles Induced by the Microinjection of Tropomyosin |
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Size = 360 x 240 pixels.| A Normal Rat Kidney cells was microinjected with human tropomyosin 3. The injection induced condensation of organelles into finger-like strands, which then collapsed into the perinuclear region. The cell retracted transiently after microinjection but re-spread afterwards. This response suggests that human tropomyosin 3 is involved in the regulation of organelle transport and distribution. |