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| Relationship between Focal Adhesions and Traction Forces |
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| K.A. Beningo, M. Dembo, I. Kaverina, J.V. Small and Y.-l. Wang (2001) |
| J. Cell Biol. 153:881-887. |
| Traction forces are presumably exerted at focal adhesions, where integrins associate with the extracellular matrix. To determine the relationship between focal adhesions and traction forces, fish fibroblasts expressing GFP-zyxin, a component of the focal adhesion, are used for simultaneous imaging of traction forces and focal adhesions. |
| Dynamics of GFP-Zyxin and Traction Forces during Cell Migration |
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| The distribution of traction stress is shown to the right as pseudocolor images, with "hot" colors corresponding to strong forces. Although many focal adhesions appear to exert strong forces, the relationship is by no means simple. Careful analysis near the leading edge indicate that weak, nascent focal adhesions generally exert stronger forces. Such inverse relationship is not found in other regions. |